12th Adhesion GPCR
Workshop 2026
Program
Registration opens at 2 p.m. on 16 September.
The scientific program starts at 3:30 p.m. on 16 September and finishes at 4:45 p.m. on 18 September.
The scientific program features a keynote lecture, seven thematic sessions, interactive poster sessions, and networking opportunities.
| Wednesday 16.09.2026 | |
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| 14:00 - 15:30 | Registration |
| 15:30 - 15:45 | Welcome |
| 15:45 - 16:45 | Keynote Lecture The long road to understanding: Early adventures in adhesion GPCR research Jörg Hamann, Amsterdam UMC (Netherlands) |
| 16:45 - 17:00 | Short Break |
| Decoding aGPCRs: Activation, Structure & Signaling | |
| 17:00 - 17:20 | The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling Sumit Bandekar, University of Chicago (United States) |
| 17:20 - 17:30 | Actin-dependent PKC delta modulation on C-tail phosphorylation of ADGRL3 Yin Kwan (Alex) Chung, University of Copenhagen (Denmark) |
| 17:30 - 17:50 | The cryo-EM structure of ADGRL4 provides functional insights into its mechanism of activation David Favara, MRC Laboratory of Molecular Biology, Cambridge (United Kingdom) |
| 17:50 - 18:10 | Cryo-EM structures of adhesion GPCR arrestin complexes: Three-tiered regulation of β-arrestin signalling encodes functional diversity across adhesion GPCRs Jin-Peng Sun, Shandong University, Jinan (China) |
| 18:10 - 18:20 | Structural and Functional Investigation of ADGRV1, a key adhesion GPCR for hearing Clarice Marty, Institut Pasteur, Paris (France) |
| 18:20 - 18:40 | Comparison of Adhesion GPCR Activation Modes Biochemically, ex vivo and in vivo using ADGRG3/GPR97 and ADGRG1/GPR56 as model receptors Gregory Tall, University of Michigan Medical School (United States) |
| 18:40 - 18:50 | GAIN domain cleavage as a protein trafficking checkpoint for adhesion GPCRs Lina Zielke, Leipzig University (Germany) |
| 18:50 - 19:00 | A new modality for adhesion GPCR signaling? TMPRSS6-dependent processing of ADGRE5/CD97 promotes receptor activation and signaling Ana Lilia Moreno Salinas, University of Sherbrooke, Québec (Canada) |
| 19:00 - 20:30 | Poster Session (with drinks and finger food) |
| Thursday 17.09.2026 | |
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| 8:30 - 9:15 | AGC General Assembly |
| 9:15 - 9:45 | Coffee Break |
| Forces at Work: Mechanosensing & Mechanical Adaptation | |
| 9:45 - 10:05 | Signaling function and Mechanosensation of the Adhesion GPCR ADGRL3 Signe Mathiasen, University of Copenhagen (Denmark) |
| 10:05 - 10:15 | Direct tensile force activates Adgrl3 in a tethered agonist-dependent manner Jesper Holmkvist, University of Copenhagen (Denmark) |
| 10:15 - 10:25 | ADGRD2 (GPR144) is required for maintenance of a straight body axis and activation of floor plate cells by the cerebrospinal fluid Claire Lebarbenchon, University of Basel (Switzerland) |
| 10:25 - 10:45 | Latrophilin-2 regulates blood flow-mediated vascular homeostasis via non-canonical G protein-independent signaling Keiichiro Tanaka, Yale University (United States) |
| 10:45 - 11:45 | Experience with antibodies against aGPCRs Rob Meijers, IPI Antibodies (United States) |
| 11:45 - 12:00 | Group photo |
| 12:00 - 13:15 | Lunch Break / Poster Session |
| Building Connections: Adhesion, Cell–Cell Communication, and synapse signaling | |
| 13:15 - 13:35 | Myelin-Associated Glycoprotein Is a cis-Regulatory Partner of ADGRL/latrophilin Antony A. Boucard, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City (Mexico) |
| 13:35 - 13:55 | Untangling excitatory versus inhibitory synapse specification by Latrophilin Adhesion GPCRs Daniel Matúš, Stanford University (United States) |
| 13:55 - 14:15 | Female-specific nociception controlled by the adhesion GPCR Remoulade Beatriz Blanco-Redondo, Leipzig University (Germany) |
| 14:15 - 14:35 | Dissecting molecular symmetry breaking in trans-intercellular complexes of Fmi/Celsr ADGRC class receptors David Strutt, University of Sheffield (United Kingdom) |
| 14:35 - 14:55 | ADGRCs in glutamatergic synapse formation and maturation Yimin Zou, The University of California, San Diego (United States) |
| 15:00 - 16:25 | AGC Board Meeting / Poster Session |
| 16:30 | Departure for City Tour |
| 18:30 | Conference Dinner |
| Friday 18.09.2026 | |
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| Shaping Tissues: Development, Polarity & Morphogenesis | |
| 8:30 - 8:50 | Investigating the role of the adhesion GPCR ADGRL/Cirl in neuronal tension homeostasis Nicole Scholz, Leipzig University (Germany) |
| 8:50 - 9:00 | ADGRL/Cirl-mediated communication within the cortex glia–neuroblast niche Lara-Sophie Brodmerkel, Leipzig University (Germany) |
| 9:00 - 9:20 | Adgrg6/Gpr126 is required for compact wall integrity and establishing trabecular identity during cardiac trabeculation Felix Engel, Friedrich Alexander University Erlangen-Nürnberg (Germany) |
| 9:20 - 9:30 | Understanding the roles of adgrg6 N-glycosylation in zebrafish tissue development Anandhu Jayachandran, Ashoka University (India) |
| 9:30 - 9:50 | A novel dominant zebrafish adgrg6 (gpr126) mutant with distinct ear defects and precocious mbpa expression Nahal Shahidan, University of Sheffield (United Kingdom) |
| 9:50 - 10:10 | WNT7A/B assemble a GPR124-RECK-LRP5/6 co-receptor complex to activate β-catenin signaling in brain endothelial cells Mario Vallon, University of Würzburg (Germany) |
| 10:10 - 10:40 | Coffee Break |
| Maintaining Balance: Organ Homeostasis & Adaptation | |
| 10:40 - 11:00 | Identification of SFTA2 as an ADGRF5 binding protein and regulator of pulmonary surfactant homeostasis James Bridges, National Jewish Health, Denver (United States) |
| 11:00 - 11:10 | Endothelial Mechanosensation as a Driver of Adipose Tissue Aging and Thermogenic Failure Anastasia Georgiadi, Helmholtz Centre Munich (Germany) |
| 11:10 - 11:30 | The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation Ines Liebscher, Leipzig University (Germany) |
| 11:30 - 11:40 | ADGRF5 prevents dilated cardiomyopathy via Gq protein/ERK1/2/STAT3-dependent repression of eccentric cardiomyocyte growth Douglas Tilley, Temple University, Philadelphia (United States) |
| 11:40 - 11:50 | The DNA repair factor ku80 binds and activates the adhesion receptor ELTD1/ADGRL4 Björn Olde, Lund University (Sweden) |
| 11:50 - 12:10 | Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke Monica Giannotta, University of Pavia (Italy) |
| 12:10 - 12:20 | Gpr56 Expression Preserves GFR in the Adenine-induced Renal Injury Mouse Ryan Martinez, University of New Mexico (United States) |
| 12:20 - 13:20 | Lunch Break |
| Responding to Challenge: Immunity, Injury & Disease | |
| 13:20 - 13:40 | Regulation of aGPCRs after traumatic injury Gabriela Aust, Leipzig University (Germany) |
| 13:40 - 14:00 | ADGRV1 regulates glutamate homeostasis in hippocampal astrocytes supporting neurons Uwe Wolfrum, Johannes Gutenberg University Mainz (Germany) |
| 14:00 - 14:10 | GPR56/ADGRG1 regulates survival of terminally differentiated CD8+ T cells Cheng-Chih Hsiao, Netherlands Institute for Neuroscience (Netherlands) |
| 14:10 - 14:30 | ADGRG1/GPR56 Couples Gα12/13-RhoA Signaling to Promote Protective Microglial States in Neurodegeneration Xianhua Piao, University of California San Francisco (United States) |
| 14:30 - 14:40 | Latrophilin2 - CFTR Interplay in Cystic Fibrosis Pathogenesis Rana El Masri, University of Geneva (Switzerland) |
| 14:40 - 15:10 | Coffee Break |
| From Mechanism to Medicine: Tools, Targets & Therapeutics | |
| 15:10 - 15:20 | A novel molecular high throughput drug screening tool for human adhesion GPCRs Prabakaran Annadurai, Leipzig University (Germany) |
| 15:20 - 15:40 | Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis, New York University Grossman School of Medicine (United States) |
| 15:40 - 16:00 | Strategies for modulating the function of axonopathy-associated variants in the adhesion GPCR BAI2 (ADGRB2) Alex Roy, Emory University (United States) |
| 16:00 - 16:45 | Poster Awards and Closing Remarks |